LOLA is a dipeptide composed of the amino acids L-ornithine and L-aspartate. L-ornithine is known for its role in the urea cycle, where it aids in the removal of ammonia from the bloodstream. Ammonia is a neurotoxic byproduct of protein metabolism, and its accumulation can lead to serious neurological complications, especially in individuals with liver dysfunction. L-aspartate, on the other hand, is involved in the synthesis of various proteins and neurotransmitters, making it essential for overall metabolic health.
In clinical nutrition, glycyl glutamine has been explored for its potential benefits in patients undergoing stress, such as those recovering from surgery, trauma, or illness. Its ability to support gut health, maintain muscle mass and facilitate healing makes it a consideration in therapeutic nutrition. Particularly, its role in preserving lean muscle mass is critical in patients experiencing catabolic states where muscle degradation exceeds synthesis.